Stress, caffeine and ethanol trigger transient neurological dysfunction through shared mechanisms in a mouse calcium channelopathy

Induction of transient neurological dysfunction in baboons by platelet microemboli.

BACKGROUND AND PURPOSE To investigate experimental mechanisms of reversible cerebral dysfunction, we produced transient focal cerebral ischemia in five baboons by unilateral perfusion of internal carotid territories with platelet microemboli generated endogenously. METHODS Platelet microemboli were formed by incorporating segments of Dacron vascular graft for 1 hour as unilateral carotid arte...

An Overview of Calcium, Mechanisms and Necessities

Today, promoting quality of life and paying more attention to nutrition and health are among the major issues of international debate and governments' strategies to improve people's quality of life in different societies. There have also been extensive studies to improve nutrition and its relationship with health. The pattern of food consumption is different in most countries, different social ...

Neural Mechanisms of Autonomic Dysfunction in Neurological Diseases

[Transient ventricular dysfunction after emotional stress].

We describe a patient who developed severe ventricular dysfunction and cardiogenic shock after intense emotional stress. Her subsequent course was favorable, with complete recovery of left ventricular systolic function. The coronary arteries were normal and no specific etiologic agent was demonstrated. Her clinical picture was compatible with transient left ventricular apical ballooning. [I123]...

Mechanisms of oxidative stress and vascular dysfunction.

The endothelium regulates vascular homoeostasis through local elaboration of mediators that modulate vascular tone, platelet adhesion, inflammation, fibrinolysis, and vascular growth. Impaired vascular function contributes to the pathogenesis of atherosclerosis and acute coronary syndromes. There is growing pathophysiological evidence that increased generation of reactive oxygen species and oxi...